SrasV1, Main, Exploration, bibRecord, 004416

SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system

Identifieur interne : 004416 ( Main/Exploration ); précédent : 004415; suivant : 004417

SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system

Auteurs : ZHENG FAN [République populaire de Chine] ; YUE ZHUO [République populaire de Chine] ; XINYU TAN [République populaire de Chine] ; ZHI ZHOU [République populaire de Chine] ; JIANGANG YUAN [République populaire de Chine] ; BOQIN QIANG [République populaire de Chine] ; JINGHUA YAN [République populaire de Chine] ; XIAOZHONG PENG [République populaire de Chine] ; George F. Gao [République populaire de Chine]

Source :

Journal of medical virology [ 0146-6615 ] ; 2006.

RBID : Pascal:06-0482826

Descripteurs français

Pascal (Inist)
- Coronavirus, Nucléocapside, Protéine, Ubiquitine, Enzyme, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Enzyme.

English descriptors

KwdEn :
- Coronavirus, Enzyme, Nucleocapsid, Protein, Severe acute respiratory syndrome, Ubiquitin.

Abstract

SARS-CoV is a newly identified coronavirus (CoV) that causes severe acute respiratory syndrome (SARS). The SARS-CoV nucleocapsid (N) protein is an important structural and functional protein. To identify cellular proteins that interact with the SARS-CoV N protein and to elucidate the possible involvement of N protein in SARS-CoV pathogenesis, a human lymphocyte cDNA library was screened using a yeast two-hybrid system assay. hUbc9, a ubiquitin conjugating enzyme of sumoylation system, was found to interact specifically with the N protein, implying the post-translational sumoylation of the N protein. Mapping studies localized the critical N sequences for this interaction to amino acids 170-210, which includes the SR-rich motif. However, the consensus motif of sumoylation GK⁶²EE in the N protein is not responsible for binding to hUbc9. Mutations of hUbc9 at the enzyme active site C93A or C93S severely impairthe interaction with the N protein. The two proteins were also shown to colocalize in the cytoplasm of the transfected 293T cells. This is the first report demonstrating the interaction of hUbc9 with a structural protein of plus-strand RNA viruses, indicating a new drug target for SARS-CoV.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000454
to stream PascalFrancis, to step Curation: 000536
to stream PascalFrancis, to step Checkpoint: 000434
to stream Main, to step Merge: 004635
to stream Main, to step Curation: 004416

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system</title>
<author><name sortKey="Zheng Fan" sort="Zheng Fan" uniqKey="Zheng Fan" last="Zheng Fan">ZHENG FAN</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yue Zhuo" sort="Yue Zhuo" uniqKey="Yue Zhuo" last="Yue Zhuo">YUE ZHUO</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Biochemistry, Anhui Agricultural University</s1>
<s2>Hefei</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Hefei</settlement>
<region type="province">Anhui</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xinyu Tan" sort="Xinyu Tan" uniqKey="Xinyu Tan" last="Xinyu Tan">XINYU TAN</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhi Zhou" sort="Zhi Zhou" uniqKey="Zhi Zhou" last="Zhi Zhou">ZHI ZHOU</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>College of Veterinary Medicine, China Agricultural University</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiangang Yuan" sort="Jiangang Yuan" uniqKey="Jiangang Yuan" last="Jiangang Yuan">JIANGANG YUAN</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boqin Qiang" sort="Boqin Qiang" uniqKey="Boqin Qiang" last="Boqin Qiang">BOQIN QIANG</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jinghua Yan" sort="Jinghua Yan" uniqKey="Jinghua Yan" last="Jinghua Yan">JINGHUA YAN</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xiaozhong Peng" sort="Xiaozhong Peng" uniqKey="Xiaozhong Peng" last="Xiaozhong Peng">XIAOZHONG PENG</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0482826</idno>
<date when="2006">2006</date>
<idno type="stanalyst">PASCAL 06-0482826 INIST</idno>
<idno type="RBID">Pascal:06-0482826</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000454</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000536</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000434</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000434</idno>
<idno type="wicri:doubleKey">0146-6615:2006:Zheng Fan:sars:cov:nucleocapsid</idno>
<idno type="wicri:Area/Main/Merge">004635</idno>
<idno type="wicri:Area/Main/Curation">004416</idno>
<idno type="wicri:Area/Main/Exploration">004416</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system</title>
<author><name sortKey="Zheng Fan" sort="Zheng Fan" uniqKey="Zheng Fan" last="Zheng Fan">ZHENG FAN</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yue Zhuo" sort="Yue Zhuo" uniqKey="Yue Zhuo" last="Yue Zhuo">YUE ZHUO</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Biochemistry, Anhui Agricultural University</s1>
<s2>Hefei</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Hefei</settlement>
<region type="province">Anhui</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xinyu Tan" sort="Xinyu Tan" uniqKey="Xinyu Tan" last="Xinyu Tan">XINYU TAN</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhi Zhou" sort="Zhi Zhou" uniqKey="Zhi Zhou" last="Zhi Zhou">ZHI ZHOU</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>College of Veterinary Medicine, China Agricultural University</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiangang Yuan" sort="Jiangang Yuan" uniqKey="Jiangang Yuan" last="Jiangang Yuan">JIANGANG YUAN</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boqin Qiang" sort="Boqin Qiang" uniqKey="Boqin Qiang" last="Boqin Qiang">BOQIN QIANG</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jinghua Yan" sort="Jinghua Yan" uniqKey="Jinghua Yan" last="Jinghua Yan">JINGHUA YAN</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xiaozhong Peng" sort="Xiaozhong Peng" uniqKey="Xiaozhong Peng" last="Xiaozhong Peng">XIAOZHONG PENG</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of medical virology</title>
<title level="j" type="abbreviated">J. med. virol.</title>
<idno type="ISSN">0146-6615</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of medical virology</title>
<title level="j" type="abbreviated">J. med. virol.</title>
<idno type="ISSN">0146-6615</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Enzyme</term>
<term>Nucleocapsid</term>
<term>Protein</term>
<term>Severe acute respiratory syndrome</term>
<term>Ubiquitin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Nucléocapside</term>
<term>Protéine</term>
<term>Ubiquitine</term>
<term>Enzyme</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enzyme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">SARS-CoV is a newly identified coronavirus (CoV) that causes severe acute respiratory syndrome (SARS). The SARS-CoV nucleocapsid (N) protein is an important structural and functional protein. To identify cellular proteins that interact with the SARS-CoV N protein and to elucidate the possible involvement of N protein in SARS-CoV pathogenesis, a human lymphocyte cDNA library was screened using a yeast two-hybrid system assay. hUbc9, a ubiquitin conjugating enzyme of sumoylation system, was found to interact specifically with the N protein, implying the post-translational sumoylation of the N protein. Mapping studies localized the critical N sequences for this interaction to amino acids 170-210, which includes the SR-rich motif. However, the consensus motif of sumoylation GK<sup>62</sup>
EE in the N protein is not responsible for binding to hUbc9. Mutations of hUbc9 at the enzyme active site C93A or C93S severely impairthe interaction with the N protein. The two proteins were also shown to colocalize in the cytoplasm of the transfected 293T cells. This is the first report demonstrating the interaction of hUbc9 with a structural protein of plus-strand RNA viruses, indicating a new drug target for SARS-CoV.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Anhui</li>
</region>
<settlement><li>Hefei</li>
<li>Pékin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zheng Fan" sort="Zheng Fan" uniqKey="Zheng Fan" last="Zheng Fan">ZHENG FAN</name>
</noRegion>
<name sortKey="Boqin Qiang" sort="Boqin Qiang" uniqKey="Boqin Qiang" last="Boqin Qiang">BOQIN QIANG</name>
<name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name>
<name sortKey="Jiangang Yuan" sort="Jiangang Yuan" uniqKey="Jiangang Yuan" last="Jiangang Yuan">JIANGANG YUAN</name>
<name sortKey="Jinghua Yan" sort="Jinghua Yan" uniqKey="Jinghua Yan" last="Jinghua Yan">JINGHUA YAN</name>
<name sortKey="Xiaozhong Peng" sort="Xiaozhong Peng" uniqKey="Xiaozhong Peng" last="Xiaozhong Peng">XIAOZHONG PENG</name>
<name sortKey="Xinyu Tan" sort="Xinyu Tan" uniqKey="Xinyu Tan" last="Xinyu Tan">XINYU TAN</name>
<name sortKey="Yue Zhuo" sort="Yue Zhuo" uniqKey="Yue Zhuo" last="Yue Zhuo">YUE ZHUO</name>
<name sortKey="Yue Zhuo" sort="Yue Zhuo" uniqKey="Yue Zhuo" last="Yue Zhuo">YUE ZHUO</name>
<name sortKey="Zhi Zhou" sort="Zhi Zhou" uniqKey="Zhi Zhou" last="Zhi Zhou">ZHI ZHOU</name>
<name sortKey="Zhi Zhou" sort="Zhi Zhou" uniqKey="Zhi Zhou" last="Zhi Zhou">ZHI ZHOU</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004416 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004416 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:06-0482826
   |texte=   SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system

SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri